Targeted magnetogenetic stimulation of malfunctioning neural circuits to address disabling brain disorders and promote healing.

Engineering biomechanical sensors

SynMech technology will create multiple novel ways to target individual synapses

Designing biocompatible magnetic nanoparticles

Our functionalized biocompatible magnetic nanoparticles will operate wirelessly

High permeability magnetic stimulators

SynMech technology includes high permeability magnetic stimulators for focal stimulation of the brain

If you look at history, innovation doesn’t come just from giving people incentives; it comes from creating environments where their ideas can connect.

Steven Johnson (born 1968), Science author & media theorist


SynMech Technology

What is SynMech

We aim to introduce an innovative magnetogenetic technology that can regulate neural circuit connectivity for therapeutic purposes in treatment-resistant brain disorders. Unlike traditional methods, our approach combines the benefits of optogenetics and magneto-mechanical stimulations, utilizing biocompatible magnetic nanoparticles and bioengineered synaptic mechanosensors to remotely control brain circuits with focused magnetic fields. This approach does not require implantation of invasive devices and has the potential to achieve subcellular resolution in repairing connectivity defects in the brain. Our interdisciplinary consortium of experts in material science, electronics, physiology and clinical fields is working towards developing this cutting-edge technology to promote normalization of neural activity in mouse models of stroke and epilepsy.


The SynMech consortium comprises 7 partners from 3 European countries, with a diverse and interdisciplinary team of established investigators and promising young researches. SynMech is committed to introduce radically new neuro-stimulation technologies and bring them from bench to bedside.

university of trieste

University of Verona

Brain Science Tools

Research Center Julic

National Research Council

University Medical Center Utrecht

German Center for Neurodegenerative Diseases


We want to share our main dissemination events for this…

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SynMech Consortium congratulates Kankana Dutta on being awarded the FENS-IBRO-PERC…

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Milan, 6 – 7 March 2023


Trends in Cell Biology

"Unlocking mechanosensitivity: integrins in neural adaptation"

Fanny Jaudon, Lorenzo A. Cingolani

Molecular Brain

"Regulation of dendritic spine length in corticopontine layer V pyramidal neurons by autism risk gene β3 integrin"

Lucia Celora, Fanny Jaudon, Carmela Vitale & Lorenzo A. Cingolani

Forschungszentrum Jülich

SYNMECH - A synaptic mechanogenetic technology to repair brain connectivity

University of Trieste

SYNMECH - A synaptic mechanogenetic technology to repair brain connectivity


we are searching for

Post Doctoral Position in Optogenetics

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Deadline 5 June 2024

PhD Student Synaptic Physiology

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Deadline 5 June 2024

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Postdoctoral Researcher to develop highly innovative technology for magnetic stimulation of specific cells and synapses

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This project has received funding from the European Union’s European Innovation Council, call HORIZON-EIC-2022-PATHFINDEROPEN-01, under Grant Agreement n.101099579