Targeted magnetogenetic stimulation of malfunctioning neural circuits to address disabling brain disorders and promote healing.
TARGETED MAGNETOGENETIC STIMULATION OF MALFUNCTIONING NEURAL CIRCUITS TO ADDRESS DISABLING BRAIN DISORDERS AND PROMOTE HEALING.
Engineering biomechanical sensors
SynMech technology will create multiple novel ways to target individual synapses
Designing biocompatible magnetic nanoparticles
Our functionalized biocompatible magnetic nanoparticles will operate wirelessly
High permeability magnetic stimulators
SynMech technology includes high permeability magnetic stimulators for focal stimulation of the brain
If you look at history, innovation doesn’t come just from giving people incentives; it comes from creating environments where their ideas can connect.
Steven Johnson (born 1968), Science author & media theorist

SynMech Technology
What is SynMech
We aim to introduce an innovative magnetogenetic technology that can regulate neural circuit connectivity for therapeutic purposes in treatment-resistant brain disorders.
Unlike traditional methods, our approach combines the benefits of optogenetics and magneto-mechanical stimulations, utilizing biocompatible magnetic nanoparticles and bioengineered synaptic mechanosensors to remotely control brain circuits with focused magnetic fields.
This approach does not require implantation of invasive devices and has the potential to achieve subcellular resolution in repairing connectivity defects in the brain. Our interdisciplinary consortium of experts in material science, electronics, physiology and clinical fields is working towards developing this cutting-edge technology to promote normalization of neural activity in mouse models of stroke and epilepsy.

partners
The SynMech consortium comprises 7 partners from 3 European countries, with a diverse and interdisciplinary team of established investigators and promising young researches. SynMech is committed to introduce radically new neuro-stimulation technologies and bring them from bench to bedside.

News
BioTalentum Joins the SynMech Consortium
We are pleased to announce that as of October 1,…
Trieste Next 2024
Exciting news! The SynMech consortium was thrilled to participate in…
Milestone 5 Achieved
Congratulations to Professor Hans-Joachim Krause and Doctor Ali Mohammad Pourshahidi…
press

Forschungszentrum Jülich
SYNMECH - A synaptic mechanogenetic technology to repair brain connectivity
JOBS
we are searching for
Postdoctoral position in synaptic physiology
Direct enquires to lcingolani@units.it by 15 December 2023
Postdoctoral Researcher to develop highly innovative technology for magnetic stimulation of specific cells and synapses
Direct enquires to alexander.dityatev@dzne.de

This project has received funding from the European Union’s European Innovation Council, call HORIZON-EIC-2022-
